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EpiCor® featured in ALETE Actives™ Immune Strength named top 3 immune-health ingredient

By September 12, 2014News and Articles, Uncategorized

From a recent Nutritional Outlook publication:

Probiotics are healthy bacteria that colonize the intestinal tract to maintain its delicate microbial balance.

Prebiotics are substances that support the growth of healthy bacteria preferentially to crowd out the less-healthy flora and promote digestive health by enhancing the production of beneficial short-chain fatty acids. And compounds that directly activate or modulate immune processes support health by optimizing multiple aspects of immune function.


EpiCor is a complex fermentation product from baker’s yeast containing antioxidants, protein, beta-glucans, fiber, polyphenols, vitamins, amino acids, and other metabolites. Several studies attest to EpiCor’s ability to modulate immune function. In a recent investigation led by Sam Possemiers from Ghent University in Belgium, EpiCor was studied using the SHIME model (described earlier) and found to have a prebiotic-like effect on gastrointestinal flora.5Changes observed included alterations in general flora profile, reduction of pathogenic strains, and increased levels of healthy Lactobacilli and Bifidobacteria. Researchers observed an increase in butyrate production and a significant decrease in pro-inflammatory cytokines.

Clinical studies support EpiCor’s ability to promote a healthy immune response in humans. Mark Moyad, the director of preventive and complementary medicine at the University of Michigan Medical Center, led a study investigating the effects of EpiCor on allergies and allergic rhinitis.6 This 12-week, placebo-controlled trial included 96 healthy subjects with a documented history of seasonal allergies and allergic rhinitis. The subjects received 500 mg of EpiCor daily or a placebo. Participants were examined at baseline and then followed up at 6 and 12 weeks. EpiCor administration significantly reduced the severity of allergic rhinitis symptoms, specifically nasal congestion and runny nose. The EpiCor group experienced 12.5 fewer days of nasal congestion compared to the placebo group and had significantly elevated salivary IgA levels (an antibody associated with enhanced mucosal immunity).

An additional 12-week study also led by Mark Moyad looked at the impact of EpiCor on cold and flu symptoms in 116 individuals with no recent history of receiving the seasonal influenza vaccine.7 Study participants were between the ages of 18 and 76 in good general health. The study was conducted during prime cold and flu season (January through March). Individuals were examined at baseline and then again at 6 and 12 weeks, and were asked to record cold or flu-like symptoms in a standardized diary. EpiCor (500 mg daily) significantly reduced the incidence of cold or flu-like symptoms compared to placebo, while non-significant decreases were noted for duration of illness compared to placebo, indicating its benefit for immune function.

While both of the above studies examined the benefits of EpiCor with sustained use, Gitte Jensen’s group at NIS Labs in Klamath Falls, OR, assessed the acute and rapid immune-modulating effects in a clinical trial with a crossover design.8 This double-blind, placebo-controlled pilot study consisted of 12 healthy subjects aged 18–54. EpiCor (500 mg) or placebo was administered on an acute basis, and measurements in the 12 subjects were taken at least two weeks apart (the washout period). At each of the two sessions, serum assessments were conducted before, and at 1 and 2 hours after, administration of the treatment for cytokines, immune cell subsets, activation status of circulating natural killer (NK) and T cells, and antioxidant protection capacity. Compared with placebo, the investigators found rapid changes in serum antioxidant status, cytokine levels, and immune surveillance capacity after the single dose of EpiCor. Moreover, the changes observed in specific lymphocyte subsets indicated a modulatory effect of EpiCor on circulating T and NK cells. The findings of this study highlight the rapid onset of EpiCor’s benefits.

Read the full article at Nutritional Outlook



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